Contraindicated (one)pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration with powerful CYP3A4 inducers; these medication cut down publicity to vandetanib by as much as forty%.
pentobarbital will lower the level or result of pimozide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
pentobarbital will reduce the level or result of conivaptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lower the level or effect of diltiazem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lower the extent or outcome of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Not known.
Watch Closely (two)pentobarbital will lessen the level or result of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid CYP3A4 inducers may perhaps lower suvorexant efficacy; if amplified suvorexant dose needed, will not exceed 20 mg/day
pentobarbital will lower the extent or impact of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Contraindicated (one)pentobarbital will reduce the level or outcome of elbasvir/grazoprevir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital raises toxicity of buprenorphine, prolonged-acting injection by pharmacodynamic synergism. Modify Therapy/Check Intently. Coadministration of buprenorphine and benzodiazepines or other CNS depressants improves possibility of adverse reactions together with overdose, respiratory despair, and Loss of life. Cessation of benzodiazepines or other CNS depressants is desired usually.
pentobarbital and daridorexant the two increase sedation. Modify Therapy/Keep an eye on Closely. Coadministration boosts danger of CNS despair, which can result in additive impairment of psychomotor performance and lead to daytime impairment.
Cessation of benzodiazepines or other CNS depressants is desired generally. Occasionally, checking at a greater level of look after tapering CNS depressants could be appropriate. In Some others, progressively tapering a patient off of click here the prescribed benzodiazepine or other CNS depressant or decreasing to the bottom successful dose may very well be acceptable.
pentobarbital will lower the extent or result of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. The efficacy of hormonal contraceptives could be lowered. Use of a nonhormonal contraceptive is recommended.
pentobarbital will reduce the level or influence of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic impact of elbasvir/grazoprevir might be decreased if coadministered with robust CYP3A inducers and it is consequently contraindicated.
pentobarbital will lessen the level or impact of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.